One of the big questions surrounding living kidney donation (uninephrectomy) is donor safety. This study looked at the survival rates, causes of death, and kidney function of Swedish kidney donors more than 20 years after donation. The study’s most significant finding was that donor survival rates were considerably higher than in the general population. This result was most likely due to the strict evaluation process (one out of three applicants is chosen), which selects for the healthiest candidates. Renal function and causes of death were similar to the general population. These findings demonstrate no long-term risk associated with uninephrectomy, suggesting the practice is safe.